Oleanolic Acid

Specification: 98% Latin Name: Ligustrum Lucidum Ait. Product Origin: Olea europaea L.’s Leaf Appearance: White needle crystal powder,no stink,tasteless Test Method: Acid-base titration Application/Function:Oleanolic acid is a naturally occurring triterpenoid,widely distributed in food and medicinal plants,related to betulinic acid.It can be found in Phytolacca americana(American pokeweed),and Syzygium spp,garlic,etc.It is relatively non-toxic,antitumor,and hepatoprotective,as well as exhibiting antiviral properties. Oleanolic acid was found to exhibit strong anti-HIV activity,the ralated compound betulinic acid was used to create the first commercial Maturation inhibitor drug.It was firststudied and isolated from several plants,including Rosa woodsii(leaves).Prosopis glandulosa(leaves and twigs),phordendron juniperinum(whole plant),Syzygium claviflorum(leaves) Hyptis capitata(whole plant),and Ternstromia gymnanthera(aerial part). Other syzygium species includng java apple that contain it. An extremely potent syntetic triterpenoid analogue of oleanolic acid was found in 2005,that are powerful inhibitors of cellular inflammatory processes.They work by the induction by IFN-of inducible nitric oxide synthase(iNOS) and of cyclooxygenase 2 in mouse macrophages.They are extremely potent inducers of the phase 2 response(e.g.,elevation of NADH-quinone oxidoreductase and heme oxygenase 1),which is a major protector of cells against oxidative and electrophile stress.