Deoxyribonuclease

Deoxyribonuclease Source: Bovine Pancrease General description Bovine pancreatic deoxyribonuclease (DNase) is an endonuclease which splits phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide yielding polynucleotides with free hydroxyl group at the 3' position and phosphate group at the 5' position. The optimum pH is 7.8. DNase I is activated by bivalent metals, and inhibited by chelating agents such EDTA and sodium dodecyl sulfate. DNase I can be stabilized against proteolytic digestion by 5 mM Ca2+. Beijing Geyuantianrun Bio-tech Co., Ltd. Deoxyribonuclease has been chromatographically purified to remove trace contaminating proteases. DNase may be used in clinic to thin and liquefy mucus in the lungs. Specification Items SpecificationMethod Appearance White or pale yellow lyophilized powderLoss on drying ≤ 0.3%K.PResidue on Ignition ≤1.0%K.PAssay No less than 500Kunitz units/mg powderSigma-Aldrich Storage Sealed, Dark, at temperature 2-8