Capsaicin

Capsaicin is a natural compound with pharmacological and toxicological effects, which given its hydrophobicity, can influence the structure of membranes. The interaction of capsaicin with model membranes of dipalmitoylphosphatidylcholine and dielaidoylphosphatidylethanolamine has been studied by using differential scanning calorimetry, fluorescent probe spectroscopy and 31P-nuclear magnetic resonance. Capsaicin remarkably affects the phase transition of dipalmitoylphosphatidylcholine, shifting the transition temperature to lower values, and giving rise, at relatively high capsaicin concentrations, to the appearance of two peaks in the thermogram. These peaks may correspond to separated phases as indicated by the partial phase diagram. Whereas capsaicin did not affect the fluorescence polarization of the probes diphenylhexatriene and trimethylammonium-diphenylhexatriene, it clearly affected that of the probe 2-anthroyloxystearic acid, indicating that the perturbation produced by capsaicin on the membrane would be mainly at the position where this fluorophore is located. On the other hand, capsaicin, at relatively low concentrations, gives rise to immiscible phases in the presence of dielaidoylphosphatidylethanolamine and decrease the temperature of the lamellar to hexagonal HII phase transition. At concentrations of capsaicin higher than 0.3 mol fraction, isotropic phases were detected. The possible implications of the effects of capsaicin on biological membranes are discussed.We provide professional plant extract, animal extract, sexual enhancement ingredients , weight loss ingredients,ingredients for reducing blood pressure,and pharmeceutical intermediates, besides, we own the speciall formula which is very effective on sexual enhancement and weight loss. If you are interested in any products, welcome to inquiry. We assure you a very competitive price and high quality.Discount is given for big quantity. Shaanxi Sciphar Biotechnology Co., Ltd. is a biological high-tech company which is primarily engaged in the research and development, production and marketing of various natural plant extracts, chemical intermediates and chemical synthetic materials. We are committed to the insurance of human health protection with our corporation culture: "manufacture sophisticated products with carefully selected natural resources; meet customers' needs with advanced quality". Capsaicin is a natural compound with pharmacological and toxicological effects, which given its hydrophobicity, can influence the structure of membranes. The interaction of capsaicin with model membranes of dipalmitoylphosphatidylcholine and dielaidoylphosphatidylethanolamine has been studied by using differential scanning calorimetry, fluorescent probe spectroscopy and 31P-nuclear magnetic resonance. Capsaicin remarkably affects the phase transition of dipalmitoylphosphatidylcholine, shifting the transition temperature to lower values, and giving rise, at relatively high capsaicin concentrations, to the appearance of two peaks in the thermogram. These peaks may correspond to separated phases as indicated by the partial phase diagram. Whereas capsaicin did not affect the fluorescence polarization of the probes diphenylhexatriene and trimethylammonium-diphenylhexatriene, it clearly affected that of the probe 2-anthroyloxystearic acid, indicating that the perturbation produced by capsaicin on the membrane would be mainly at the position where this fluorophore is located. On the other hand, capsaicin, at relatively low concentrations, gives rise to immiscible phases in the presence of dielaidoylphosphatidylethanolamine and decrease the temperature of the lamellar to hexagonal HII phase transition. At concentrations of capsaicin higher than 0.3 mol fraction, isotropic phases were detected. The possible implications of the effects of capsaicin on biological membranes are discussed.We provide professional plant extract, animal extract, sexual enhancement ingredients , weight loss ingredients,ingredients for reducing blood pressure,and pharmeceutical intermediates, besides, we own the speciall formula which is very effective on sexual enhancement and weight loss. If you are interested in any products, welcome to inquiry. We assure you a very competitive price and high quality.Discount is given for big quantity.Shaanxi Sciphar Biotechnology Co., Ltd. is a biological high-tech company which is primarily engaged in the research and development, production and marketing of various natural plant extracts, chemical intermediates and chemical synthetic materials. We are committed to the insurance of human health protection with our corporation culture: "manufacture sophisticated products with carefully selected natural resources; meet customers' needs with advanced quality".