Tribenuron-甲基75%的工作组，以Tribenuron-甲基95%的技术合作

Tribenuron-methyl 75%WG Tribenuron-Methyl NOMENCLATURE Chemical Abstracts name methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulfonyl]benzoate CAS RN [101200-48-0] EEC no. 401-190-1 Development codes DPX-L5300 (Du Pont); L5300 tribenuron Common name tribenuron (BSI, ANSI, draft E-ISO) IUPAC name 2-[4-methoxy-6-methyl-1,3,5-triazin-2-yl(methyl)carbamoylsulfamoyl]benzoic acid Chemical Abstracts name 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)methylamino]carbonyl]amino]sulfonyl]benzoic acid CAS RN [106040-48-6] Tribenuron-Methyl APPLICATIONS Biochemistry Branched chain amino acid synthesis (ALS or AHAS) inhibitor. Acts by inhibiting biosynthesis of the essential amino acids valine and isoleucine, hence stopping cell division and plant growth. Selectivity derives from rapid metabolism in the crop. Metabolic basis of selectivity in sulfonylureas reviewed (M. K. Koeppe & H. M. Brown, Agro-Food-Industry, 6, 9-14 (1995)). Mode of action Rapidly absorbed by foliage and roots and translocated throughout the plant. Susceptible plants cease growth almost immediately after post-emergence treatment and are killed in 7-21 days. Surfactants increase the activity of tribenuron-methyl on certain broad-leaved weeds. Uses Post-emergence control of broad-leaved weeds in spring and winter cereals, at 9-30 g/ha. Formulation types TB; WG. Selected tradenames: 'Express' (USA) (Du Pont); 'Granstar' (Europe) (Du Pont); 'Pointer' (Germany) (Du Pont) Tribenuron-Methyl OTHER TRADENAMES'Cameo' (Du Pont); 'Quantum 75' (Du Pont); 'Quantum' (Du Pont); 'Oscar' (Vapco) mixtures: 'Calibre' (+ thifensulfuron-methyl) (Du Pont); 'Canvas' (+ METSULFURON-METHYL+ THIFENSULFURON-METHYL) (Du Pont); 'DUK 110' (+ thifensulfuron-methyl) (Du Pont); 'Harmony Extra' (+ thifensulfuron-methyl) (Du Pont) Tribenuron-Methyl ANALYSIS Product and residue analysis by hplc. Methods for sulfonylurea residues in crops, soil and water reviewed (A. C. Barefoot et al., Proc. Br. Crop Prot. Conf. - Weeds, 1995, 2, 707). Tribenuron-Methyl MAMMALIAN TOXICOLOGY Oral Acute oral LD50 for rats >5000 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >2000 mg/kg. Non-irritating to skin (rabbits); mild (reversible) irritant to eyes. Mildly sensitising to skin (guinea pig maximisation test). Inhalation LC50 (4 h) for rats >5.0 mg/l air. NOEL (2 y) for rats 25 ppm diet; (18 mo) for mice 200 ppm diet (30 mg/kg b.w. daily); (1 y) for dogs 250 ppm diet (8.2 mg/kg b.w. daily); (90 d) for rats 100, for mice 500, for dogs 500 mg/kg diet. Non-teratogenic in rats at 20 mg/kg daily. ADI 0.008 mg/kg. Other Non-mutagenic in the Ames test, and negative in CHO, unscheduled DNA, in vivo cytogenetic, in vivo mouse micronucleus, and in vitro human lymphocyte assays. Toxicity class WHO (a.i.) III (Table 5); EPA (formulation) III EC hazard R43