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1. SAMe What’s SAMe? S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. Supplementing with SAMe The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe and Joint Function SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe and Neural Health SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe and Liver Function SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.* Our SAMe 1.1 S-Adenosyl-L-Methionine Disulfate p-toluenesulfonate CAS No.: 97540-22-2 Appearance: Almost white powder(very hygroscopic) Dry content: > 98% Specification: 25kg/drum, can be changed per requested Use: Nutrition industry 1.2 S-Adenisy-Methionine 1,4-Butanedisulfonate(SAMe SD4) CAS No.: 29908-03-0 Appearance: Almost white powder(very hygroscopic) Dry content: > 98% Specification: 25kg/drum, can be changed per requested Use: higher content and stability, suitable for pharmaceutical production