Resveratrol

Grape SkinExtract Resveratrol ProductSpecification:1%-5%Resveratrol LatinName:Vitis vinifera ExtractMethod:GrainAlcohol/Water Whatisresveratrol: Resveratrol(trans-3,5,4'-trihydroxystilbene),belongstoaclassofpolyphenoliccompoundscalledstilbenes,foundlargelyintheskinsofredgrapesandrootofPolygonumcuspidatumSieb.etZucc(Japaneseknotweed),isacomponentofKo-jo-kon,anorientalmedicineusedtotreatdiseasesofthebloodvessels,heartandlive..Resveratrolisafat-solublecompoundthatoccursinatransandacisconfiguration(seefigure1).Bothcis-andtrans-resveratrolalsooccurasglucosides(boundtoaglucosemolecule).Resveratrol-3-O-beta-glucosideisalsocalledpiceid. Wheredoesthisproductapplyto? CardiovascularEffects Manystudiessuggestthatconsumingalcohol(especiallyredwine)mayreducetheincidenceofcoronaryheartdisease(CHD).Severalstudieshavedemonstratedthatresveratrolisaneffectiveantioxidant.Itinhibitslipidperoxidationoflow-densitylipoprotein(LDL),preventsthecytotoxicityofoxidizedLDL,andprotectscellsagainstlipidperoxidation.Itisthoughtthatbecauseitcontainshighlyhydrophilicandlipophilicproperties,itcanprovidemoreeffectiveprotectionthanotherwell-knownantioxidants,suchasvitaminsCandE.Ontheotherhand,itislesseffectivethantheantioxidantsquercetinandepicatechinfoundinredwine.Reducedplateletaggregationhasalsobeendemonstratedinstudiesonresveratrol,furthercontributingtoitspreventionofatherosclerosis.Todate,mostoftheresearchonresveratrol'santioxidantandanti-plateletpropertieshasbeendoneinvitro(inanartificialenvironmentusingtest-tubeortissue-culturepreparations).Furtherstudiesinanimalsandhumansarenecessarytodeterminewhetherresveratrolsupplementationmakessense. Cancer-RelatedEffects Resveratrolisbeingstudiedtoseehowitaffectstheinitiation,promotion,andprogressionofcancer.Withregardtotumorinitiation,ithasbeenshowntoactasanantioxidantbyinhibitingfreeradicalformation,andasananti-mutageninratmodels.Resveratrolappearstodecreasetumorpromotionactivitybyinhibitingcyclooxygenase-1(COX-1),anenzymethatconvertsarachidonicacidtopro-inflammatorysubstancesthatstimulatetumor-cellgrowth.Studiesrelatedtoprogressionhavefoundthatresveratrolinducedhumanpromyelocyticleukemiacelldifferentiationandinhibitedribonucleotidereductase,anenzymeneededforDNAsynthesisinproliferatingcells.Oneappealingcharacteristicofresveratrol'santi-cancerpotentialisitsminimaltoxicitytoblood-formingcells.Morestudiesusingbothcellularandanimalmodelsareneededbeforeanysuchdatawouldbeapplicabletohumanuse. Thesimilarityinstructurebetweenresveratrolanddiethylstilbestrol(asyntheticestrogen)haspromptedinvestigationsintoresveratrol'spotentialasaphytoestrogen(aplantcompoundthatproducesestrogen-likeeffects).However,thesepropertiesalsostimulatethegrowthofhumanbreastcancercells.Thisfindingseemscontrarytoitsotheranticanceractivities,andisacauseforconcern. TheNaturalProductsAssociationwascitedinanarticleregardinganewdietarysupplementthatcontainsresveratrol,asubstanceresearchersbelievemayhelpprotecthumancellsfromdiseasessuchascancerandarthritis. PackingDetail: Packedinpaper-drumsandtwoplastic-bagsinside.Netweight:25kgs/drum. Storagesituation: Storedinacoolanddrywell-closedcontainer,keepawayfrommoistureandstronglight/heat. Shelflife: Twoyearsunderwellstoragesituationandstoredawayfromdirectsunlight.