piroctone olamine

. Efficacy The scalp depends itself against micro-organisms and fungus infections. The defence system protects the scalp against all kinds of influences that it is expose to. Sometimes this defence system becomes weakened and a certain fungus infection develops called Pityrosporum Ovale. This fungus infection causes considerable cell multiplication. The skin is no longer in a position to defend itself; the scaling becomes rapid, and starts to gather on the scalp. A superfluous cell situation mixing with skin sebum causes dandruffto be formed. People with dandruff experience itchiness of the scalp. Besides this, theirproblem is very often an ongoing one. Piroctone olamine is an anti-dandruff active ingredient, soothes inflamed scalp and reduces flaking. It has a specific action against Pityrosporum Ovale, the agent responsible for the production of dandruff. The anti-dandruff product containing piroctone olamine destroys the fungus infection that is responsible for the dandruff and works against the formation of new dandruff, makes the scalp stays clean, itch free and prevents the formation of new dandruff, you become free of all the inconvenience relating to dandruff. After six weeks of treatment, the scalp dandruff decreased 81.7 % by using a shampoo containing 0.5% piroctone olamine, and 68.6% by a 0.5% Zinc pyrithione shampoo. 4. Toxicity Acute toxicity: Acute oral LD50 –rat 8100mg/kg, practically nontoxic. Subchronic toxicity: NOEL: 100mg//kg/d (rat, orally, 3 months). Chronic toxicity and carcinogencity: Negative. Mutagenicity: Negative. Irritation to skin and eye: Very low. 5. Special Functions of Piroctone Olamine The reason that piroctone olamine finds favour in the eyes of manufacturer and technicians is not only because of its good antidandruff action, solubility and safety, butalso its special functions such as thickening preservation and elemination of body offensive odour.