Chitosan(粉末)

Chitosan Specification 1) Common Chitosan (Medical/Food Grade) Deacetylation Degree: 85%,90%,95% 2) High-density Chitosan General indroduction Chitosan (pronounced ) is a linear composed of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and (acetylated unit). It has a number of commercial and possible biomedical uses.Chitosan is produced commercially by of , which is the structural in the of crustaceans (crabs, shrimp, etc.) and cell walls of fungi. The degree of deacetylation (%DD) can be determined by NMR , and the%DD in commercial chitosans is in the range 60-100%. The amino group in chitosan has a pKa value of 6.5, thus, chitosan is positively charged and soluble in acidic to neutral solution with a charge density dependent on pH and the%DA-value. This makes chitosan a bioadhesive which readily binds to negatively charged surfaces such as mucosal membranes. Chitosan enhances the transport of polar drugs across epithelial surfaces, and is and biodegradable. Purified qualities of chitosans are available for biomedical applications Chitosan and its derivatives such as trimethylchitosan (where the amino group has been trimethylated) have been used in non-viral gene delivery. Trimethylchitosan, or quaternised chitosan, has been shown to breast cancer cells; with increased degree of trimethylation increasing the cytotoxicity and at approximately 50% trimethylation the derivative is the most efficient at gene delivery. Oligomeric derivatives (3-6 kDa) are relatively non-toxic and have good gene delivery properties. Function and application Industrial useScientists have recently developed a polyurethane coating that heals its own scratches when exposed to sunlight, offering the promise of scratch-free cars and other products. The self-healing coating uses chitosan incorporated into traditional polymer materials, such as those used in coatings on cars to protect paint. When a scratch damages the chemical structure, the chitosan responds to ultraviolet light by forming chemical chains that begin bonding with other materials in the substance, eventually smoothing the scratch. The process can take less than an hour. Marek W. Urban, a scientist working on this project said that the polymer can only repair itself in the same spot once, and would not work after repeated scratches. Biomedical useChitosan's properties allow it to rapidly clot blood, and has recently gained approval in the United States and Europe for use in bandages and other . Chitosan hemostatic products have been shown in testing by the to quickly stop bleeding and result in 100% survival of otherwise lethal arterial wounds in swine and to reduce blood loss. Chitosan hemostatic products reduce blood loss in comparison to gauze dressings and increase patient survival. Chitosan hemostatic products have been sold to the and are currently used by the UK military. Both the US and UK have already used the bandages on the battlefields of and . Chitosan is hypoallergenic, and has natural anti-bacterial properties, further supporting its use in field bandages. COA fyr Test items Specifications Test results Appearance Almost white powder Complies Solubility Soluble in acid, but insoluble in alkali and water or in ordinary organic solvent. Complies DAC degree ≥95% 96.07% Viscosity 50mpa.s—200mpas.s 115mpa.s Moisture ≤10.0% 7.40% Ash content ≤1.5% 0.94% Heavy metals ≤10ppm Complies Arsenic ≤1.0ppm Complies Lead ≤2.0ppm Complies Mercury ≤0.5ppm Complies Cadmium ≤1.0ppm Complies Particle Size 100Mesh Complies Density ≥0.70g/ml 0.82g/ml Total plate count ≤1000cfu/g <500cfu/g Yeast & Mold ≤100cfu/g <10cfu/g E.COLI negative negative Salmonella negative negative Should any interest or any pending enquiry, pls donot hesitate to contact me. (Ms.)Joy Zhang Xiamen Forever Green Source Biochem Tech. Co., Ltd. Tel: 0086-592-5812532 Fax: 0086-592-5639276/5185053