Product details Ingeridents:Cortex Fraxini,Pyrethrum tatsienense,fossil bone,Bulbus Fritillariae Cirrhosae Property:This product is hard capsule,the contents are light yellow powders .It is slightly bitter in taste. Funciton:Promote blood circulation to remove blood stasis;heal and bone joiner,relieve pain.It is suitable for such sympotoms asfracture ,peristeal injuries,bad bone healing ,acute or chronic oteomyelitis,musclse sprains,blood stasis ,swelling and aching etc. Usage and dosage:Oral administration ,3 pills one time,3 times one day. Adverse reaction:Uncertainty. Contraindication:Uncertainty. Notes: Uncertainty. OEM service offered. Storeage:Air-proof. Package:PTP aluminum foil for pharmaceutical packaging,PVC solid medicinal hard film. Detailed clinical information Acute toxicity test The doses of mice taking this medication is equivalent to 577 times adult doses per day,even so ,it can’t lead to the death of animal.Furthermore,no any toxic reaction is observed,which demonstrate that the drug has a lower toxicity,higher safety in oral administration,and clinical use is available. Long toxicity test The Wistar rat had been taking this drug for 90 days in 0.975g/kg,10950g/kg,and 3.900g/kg respectively.The test show that the growth and development of rat are very well,no death observed.Compared with blank control group,the tested animals have not been observed significant difference in animal appearance,behavioral activity,weight growth,blood index and so on,such as main organ coefficient,liver function,kidney function,AKP,blood calcium,phosphorus etc.And also,the light microscope inspection found that the main organs structures, such as heart,liver and spleen,lung,kidney,and adrenal gland etc,have no abnormalities.Furthermore,the rats taked this meidication have not been found significant toxicity changes,which presented that the drug has a lower toxicity,and is very safe. Clinical research The drug has cured 140 patients with limb fracture,compared with other 70 patients taking other orthopedics medication (sheng ke jie gu tablet),this product has achieved good results. Test result 1.Sheet 1 Comparison of effect on relieving swelling and pain Groupcasesthe time of relieving swelling and pain(d) ≤8 9-13 14-1617-20≥21 Treatment group140116 (82.9)3(2.14) 2(1.43)0(0.0)19(13.57) Contrast group7056(80) 4(10.01) 5(7.14)1(1.14)1(1.4)Note:compared with contrast group P>0.5 From the above,the time of relieving swelling and pain is similar in two groups. 2. Sheet 2 Comparison of callus seen Groupcases the time of callus seen23456Treatment group14031(22.2)65(46.4)36(25.7)8(5.7)0(0.0) Contrast group707(10.0)17(24.3)29(41.4)13(18.6)4 (5.7) Note:P>0.01 Compared with sheng ke jie gu tablets,this drug has a earlier time of callus seen.by Ridit analysis, it has a significant meanings. 3.Safety assessment The patients of two groups have done examination of blood,urine,ECG,liver and kidney between treatments.No abnormal result changes,no significant adverse reaction. Brief summary The excellent rate of this drug is 100.0% in the effect of relieving swelling and pain,but the contrast is 75.7%,so this product has a good effect.There are 96 cases that the callus was founded after taking the drug 2 3 weeks,which accout for 68.6%,but the contrast is 24 cases ,accouted for 34.3%.The healing time shortened 2.2 4.3 weeks than the contrast group.After taking the drug,most patients have a better tongue pulse,and no adverse reactions were founded.Moreover,it has no impact on liver and kidney function.This product takes effect rapidly,which enhanced the confidence to overcome the pain and laid the foundation for early recovery of patient.